Waters ACQUITY UPLC H-Class System

With dispersion of less than 10 μL, the ACQUITY UPLC H-Class System delivers the highest resolution of any quaternary LC system in the market. Achieving true UPLC performance requires that system dispersion (or extra-column band spread) be matched to the peak widths associated with narrowbore columns packed with sub-2-μm particles.  While other systems might be designed for high pressure, it doesn’t mean they're designed to deliver the sharp peaks associated with UPLC performance and the ACQUITY UPLC H-Class System.

Highest resolution of any quaternary LC system
  • Improve your laboratory’s efficiency by scaling your methods to UPLC Technology
  • Use UPLC’s unmatched resolution to get better characterization of your complex samples
  • Take advantage of tools that simplify and streamline your method development workflow
  • Future-proof your lab by running your existing HPLC and UHPLC methods today and then transitioning to UPLC when you are ready

The Waters® ACQUITY UPLC® H-Class System delivers the flexibility of quaternary solvent blending with the advanced performance of UPLC® separations. The system’s holistic design is targeted for routine analysis and method development use and is perfectly suited for running both HPLC and UPLC applications while still realizing the improved resolution and sensitivity of UPLC separations. The system is comprised of a Quaternary Solvent Manager (QSM), a Sample Manager with Flow-Through Needle (SM-FTN) design, and offers a choice of column compartment products.


  • Multi-solvent blending. The QSM blends four solvents in any combination or proportions. Expand to up to nine solvent choices with the optional internal-solvent
  • Direct inject sampling.
  • Next-generation column compartments.
  • Easy-to-access, low-volume, active solvent pre-heaters, resulting in the same efficiency system to system